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TOPIC: Effect of Probiotic VSL #3 and Omega 3

Effect of Probiotic VSL #3 and Omega 3 19 Jan 2018 20:22 #11004

  • Debra
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Good news on Probiotics and Omega 3s on Inflammation!

Mediators of Inflammation
Volume 2014 (2014), Article ID 348959, 8 pages

Clinical Study
Effect of Probiotic (VSL#3) and Omega-3 on Lipid Profile, Insulin Sensitivity, Inflammatory Markers, and Gut Colonization in Overweight Adults: A Randomized, Controlled Trial

Hemalatha Rajkumar, Naseha Mahmood, Manoj Kumar, Sudarshan Reddy Varikuti, Hanumanth Reddy Challa, and Shiva Prakash Myakala

Department of Microbiology and Immunology, National Institute of Nutrition, ICMR, Hyderabad 500007, India

Received 13 January 2014; Revised 22 February 2014; Accepted 25 February 2014; Published 26 March 2014

Academic Editor: Ishak Ozel Tekin


To evaluate the effects of probiotic (VSL#3) and omega-3 fatty acid on insulin sensitivity, blood lipids, and inflammation, we conducted a clinical trial in 60 overweight (), healthy adults, aged 40?60 years. After initial screening the subjects were randomized into four groups with 15 per group. The four groups received, respectively, placebo, omega-3 fatty acid, probiotic VSL#3, or both omega-3 and probiotic, for 6 weeks. Blood and fecal samples were collected at baseline and after 6 weeks.

The probiotic (VSL#3) supplemented group had significant reduction in total cholesterol, triglyceride, LDL, and VLDL and had increased HDL () value. VSL#3 improved insulin sensitivity (), decreased hsCRP, and favorably affected the composition of gut microbiota.

Omega-3 had significant effect on insulin sensitivity and hsCRP but had no effect on gut microbiota. Addition of omega-3 fatty acid with VSL#3 had more pronounced effect on HDL, insulin sensitivity and hsCRP. Subjects with low HDL, insulin resistance, and high hsCRP had significantly lower total lactobacilli and bifidobacteria count and higher E. coli and bacteroides count.

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