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TOPIC: Tainted Milk May Cause Crohn's Disease

Tainted Milk May Cause Crohn's Disease 01 Oct 2008 18:44 #662

  • Debra
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A New Study shows Tainted Milk may cause Crohn's Disease

A bacterium known to cause illness in cattle may also cause Crohn's disease in humans. Crohn's disease causes chronic intestinal inflammation, leading to pain, bleeding and diarrhea.

A bacterium called Mycobacterium paratuberculosis prevents white blood cells from killing E. coli bacteria. E. coli is known to be present in increased numbers within Crohn’s disease infected tissue.

It is believed that the Mycobacteria make their way into the body’s system via cows’ milk and other dairy products

Microbial mannan inhibits bacterial killing by macrophages: a possible pathogenic mechanism for Crohn's disease.
Mpofu CM , Campbell BJ , Subramanian S , Marshall-Clarke S , Hart CA , Cross A , Roberts CL , McGoldrick A , Edwards SW , Rhodes JM .
Division of Gastroenterology, School of Clinical Science, University of Liverpool, Liverpool, United Kingdom.

BACKGROUND & AIMS: Crohn's disease (CD) is mimicked by inherited phagocyte disorders and is associated with circulating antibodies against yeast mannan (anti-Saccharomyces cerevisiae antibody; ASCA). We speculated that mannans might impair phagocyte function. METHODS: S cerevisiae mannan was assessed for its effects on human peripheral blood neutrophils, adherent monocytes, and monocyte-derived macrophages (MDM).

RESULTS: Mannan caused dose-related increased survival of CD Escherichia coli HM605 within adherent monocytes from 24% +/- 10.5% (control) to 114% +/- 22.7% with mannan 1 mg/mL at 2 hours (mean +/- SEM, n = 9; P = .0002). Electron microscopy showed E coli HM605 surviving and probably replicating within macrophage vesicles. Mannan (1 mg/mL) inhibited the respiratory burst in neutrophils and monocytes (both P = .002) and bacterial killing within MDM (P < .001). E coli survival was increased within macrophages from TLR4(-/-) (126% +/- 3.5% survival at 2 hours) and MyD88(-/-) (134.8% +/- 6.5%) mice compared with wild-type mice (both P < .0001). Mannan had no additional effect, showing that TLR4 and MyD88 are involved in bacterial killing by macrophages and its inhibition by mannan. Putative CD-associated micro-organisms were screened for the ASCA mannan epitope by Galanthus nivalis lectin (GNA) blotting. ASCA epitope was expressed by Candida albicans and Mycobacterium paratuberculosis but not by Mycobacterium tuberculosis or E coli. Supernatants from M paratuberculosis culture inhibited killing of E coli HM605 by adherent human monocytes and murine macrophages. The inhibitory activity was removed by GNA-affinity chromatography.

CONCLUSIONS: Suppression of mucosal phagocyte function by microbial mannans, possibly of Mycobacterial origin, may contribute to CD pathogenesis.

PMID: 17919633 [PubMed - indexed for MEDLINE]
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