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TOPIC: Food Specific IgG antibody-guided exclusion diet

Food Specific IgG antibody-guided exclusion diet 25 Jan 2009 15:38 #666

  • Debra
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I'm posting this research article due to the number of unexplained IBS symptoms in many of my clients. I leave it up to you to eliminate the suggested foods inside the conclusion in bold. You will notice that the Cycle Diet eliminates all but eggs and wheat (except for the GF plan) in the luteal phase on the increased antibodies IgG4 food list....I find this research article a confirmation of what I've noticed in my clients who suffer from PMS/PMDD.

**Important to remember:Constant or frequent diarrhea is a sign of inflammation, inflammation=malabsorption. Malabsorption= Vitamin and mineral deficiency.

Scand J Gastroenterol.
2005 Jul;40(7):800-7.

Food-specific IgG4 antibody-guided exclusion diet improves symptoms and rectal compliance in irritable bowel syndrome.
Zar S , Mincher L , Benson MJ , Kumar D .
OGEM Department, St George's Hospital Medical School, London, UK.

OBJECTIVE: Dietary modification improves symptoms in irritable bowel syndrome (IBS). Identification of offending foods by dietary elimination/re-challenge is cumbersome. IgG4 antibodies to common food antigens are elevated in IBS. The aim of this article was to evaluate the effect of exclusion diet based on IgG4 titres on IBS symptoms and rectal sensitivity and compliance.


 MATERIALS AND METHODS: The study comprised 25 patients with IBS (3 M, 22 F, mean age 43 years, Rome II criteria). IgG4 titres to 16 foods (milk, eggs, cheese, wheat, rice, potatoes, chicken, beef, pork, lamb, soya bean, fish, shrimps, yeast, tomatoes and peanuts) were measured. Foods with titres >250 microg/l were excluded for 6 months. Symptom severity was assessed with a previously validated questionnaire at baseline, at 3 months and at 6 months. Rectal compliance and sensitivity were measured in 12 patients at baseline and at 6 months.


RESULTS: IgG4 antibodies to milk, eggs, wheat, beef, pork and lamb were commonly elevated. Significant improvement was reported in pain severity (p < 0.001), pain frequency (p = 0.034), bloating severity (p = 0.001), satisfaction with bowel habits (p = 0.004) and effect of IBS on life in general (p = 0.008) at 3 months. Symptom improvement was maintained at 6 months. Rectal compliance was significantly increased (p = 0.011) at 6 months but the thresholds for urge to defecate/discomfort were unchanged.


CONCLUSIONS: Food-specific IgG4 antibody-guided exclusion diet improves symptoms in IBS and is associated with an improvement in rectal compliance.


PMID: 16109655 [PubMed - indexed for MEDLINE]

Food Specific IgG antibody-guided exclusion diet 04 May 2009 12:01 #667

  • Debra
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