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TOPIC: High-Dose vitamin D Shown to Alleviate Painful Cramps

High-Dose vitamin D Shown to Alleviate Painful Cramps 02 Mar 2012 12:20 #4264

  • Debra
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[font="verdana, arial, helvetica, sans-serif"]Only the first 150 words of this Italian study was provided. The findings/and results of this study was also duplicated here in the US as well. The dose of the 1 time vitamin D injection was 300,000 IU's and worked for 2 months in women with severe menstrual cramps. This dose works out to 5,000 IU's a day, which is 3,000 IU's over the current upper limits on vit D set at 2,000 IUs. I normally recommend 2,000 IU's a day in women with PMS/PMDD especially in the winter months.


Primary dysmenorrhea is a common disorder characterized by painful uterine cramping, just before or during menstruation, in the absence of any pelvic pathologic conditions. It is frequently accompanied by other symptoms such as nausea, vomiting, diarrhea, asthenia, and insomnia.1-2 Primary dysmenorrhea affects almost half of menstruating women, often resulting in school and work absenteeism with major educational and economic consequences.2 An excessive uterine production of prostaglandins (PGs) is the pathogenetic trigger of dysmenorrhea. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the currently accepted drugs for the management of this disorder.1-2 Because the vitamin D receptor is widespread and the mitochondrial cytochrome P450 enzyme 25-hydroxyvitamin D3 (25[OH]D)-1α-hydroxylase (1α-OHase), which catalyzes the synthesis of 1α,25-dihydroxyvitamin D3 (1,25[OH]2D) from its precursor 25(OH)D, is expressed in the human uterus and in immune system cells, and because vitamin D reduces the synthesis of PGs, a beneficial effect

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