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Articles and research studies related to PCOS. This forum is open to the public. PCOS is an autoimmune condition.
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TOPIC: PCOS & Serum Zonulin

PCOS & Serum Zonulin 26 Oct 2014 12:15 #10058

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More evidence all women with PCOS should be on a gluten-free diet!

Eur J Endocrinol. 2014 Oct 21. pii: EJE-14-0589. [Epub ahead of print]
Serum zonulin is elevated in women with polycystic ovary syndrome, and correlates with insulin resistance and severity of anovulation.
www.ncbi.nlm.nih.gov/pubmed/25336505

Abstract

Objective: Evidence suggests that increased gut permeability may be associated with polycystic ovary syndrome (PCOS). Human zonulin is currently the only physiological mediator known to regulate gut permeability reversibly by disassembling intestinal tight junctions. So far, no data on serum zonulin levels in patients with PCOS is available. This study aimed to determine circulating serum zonulin levels in women with PCOS, and discuss the relationship between zonulin, insulin resistance and menstrual disorders in this group.
Design: Case-control study.
Methods: Seventy-eight women recently diagnosed with PCOS, and 63 age matched healthy controls were recruited for this study. Serum zonulin levels were determined by ELISA. Insulin resistance was assessed by homeostasis model assessment of insulin resistance (HOMA-IR) and Matsuda and DeFronzo's insulin sensitivity index (ISI).

Results: PCOS women had higher serum zonulin (p=0.022). After adjustment for age and body mass index, zonulin levels significantly correlated with HOMA-IR and ISI. Furthermore, PCOS women with more severe menstrual disorders had significantly higher zonulin levels and displayed an inverse correlation between zonulin and the number of menstrual cycles per year (r=-0.398, p<0.001).
Conclusions: Serum zonulin, a biomarker for gut permeability, is increased in PCOS women, and correlates with insulin resistance and severity of menstrual disorders. It suggests that alterations of gut permeability may play a role in the patho-physiology of PCOS, and serum zonulin might be used as a biomarker for both risk stratification and therapeutic outcomes in PCOS women.

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One woman's nutrient is another woman's antigen
Listen to your body, it's talking to you

PCOS & Serum Zonulin 22 May 2015 14:28 #10233

  • Debra
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One woman's nutrient is another woman's antigen
Listen to your body, it's talking to you
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