Forgot Password       
×

Notice

The forum is in read only mode.
Welcome, Guest
Username: Password: Remember me
Articles and research studies related to PCOS. This forum is open to the public. PCOS is an autoimmune condition.
  • Page:
  • 1

TOPIC: Is PCOS an Autoimmune disease?

Is PCOS an Autoimmune disease? 09 Jul 2008 20:11 #789

  • Debra
  • Debra's Avatar Topic Author
  • Offline
  • Administrator
  • Administrator
  • CycleDiet Registered Dietitian
  • Posts: 2416
  • Karma: 3
  • Thank you received: 129
An interesting statement was made regarding PCOS not being autoimmune, but every indication is that it is according to these researchers:

Autoimmun Rev. 2007 Nov;7(1):42-5. Epub 2007 Jul 18.

Functional autoantibodies, a new paradigm in autoimmunity?
Gleicher N , Barad D , Weghofer A .
Center for Human Reproduction, New York, New York, USA. This email address is being protected from spambots. You need JavaScript enabled to view it.

The recent detection of stimulatory autoantibodies as a characteristic feature of systemic sclerosis (scleroderma), established the presence of such autoantibodies as a characteristic pathophysiologic finding in a second classical autoimmune disease after autoimmune thyroid disease. This observation raises the possibility of a new paradigm in abnormal autoimmune function, the presence of stimulatory (and suppressive), functional autoantibodies as characteristic features of abnormal autoimmune function. The assumption of such a paradigm opens interesting new research avenues within rheumatology and in other medical specialty areas. Within reproductive medicine, and akin to the concept of hypo- and hyperthyroidism, the possible juxtaposition of polycystic ovarian syndrome (PCOS) and premature ovarian aging (POA), as opposite abnormalities of adrenal function, under control of autoimmune adrenal antibodies, deserves further investigation.

Eur J Endocrinol. 2004 Mar;150(3):363-9.
High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome
[size=+1]OE Janssen, N Mehlmauer, S Hahn, AH Offner, and R Gartner [/size]
Division of Endocrinology, Department of Medicine, University of Essen, Essen, Germany.

Abstract
OBJECTIVE: To investigate the prevalence of autoimmune thyroiditis (AIT) in patients with polycystic ovary syndrome (PCOS). DESIGN: Over a period of 30 months, 175 patients with PCOS were recruited to a prospective multicenter study to evaluate thyroid function and morphology; 168 age-matched women without PCOS were studied as a control group. METHODS: PCOS was defined as a- or oligomenorrhea, hyperandrogenism and exclusion of other disturbances of estrogen or androgen synthesis. All laboratory parameters were determined with automated immunoassays. Thyroid morphology was assessed by ultrasound. RESULTS: PCOS patients were characterized by an increased LH/FSH ratio, low progesterone, elevated testosterone and a high prevalence of hirsutism (PCOS 83%, control 3%; mean hirsutism score 12+/-5 and 3+/-2 respectively), but no differences in estrogen levels were found. Thyroid function and thyroid-specific antibody tests revealed elevated thyroperoxidase (TPO) or thyroglobulin (TG) antibodies in 14 of 168 controls (8.3%), and in 47 of 175 patients with PCOS (26.9%; P<0.001). On thyroid ultrasound, 42.3% of PCOS patients, but only 6.5% of the controls (P<0.001) had a hypoechoic tissue typical of AIT; while thyroid hormone levels were normal in all subjects, PCOS patients had a higher mean TSH level (P<0.001) and a higher incidence of TSH levels above the upper limit of normal (PCOS 10.9%, controls 1.8%; P<0.001).
CONCLUSION: This prospective study demonstrates a threefold higher prevalence of AIT in patients with PCOS, correlated in part with an increased estrogen-to-progesterone ratio and characterized by early manifestation of the disease.

1: Am J Reprod Immunol. 2005 Nov;54(5):262-9.

IgG, IgA and IgM antibodies against FSH: serological markers of pathogenic autoimmunity or of normal immunoregulation?
Haller K , Mathieu C , Rull K , Matt K , Béné MC , Uibo R .
Department of Immunology, Institute of General and Molecular Pathology and Centre of Molecular and Clinical Medicine, University of Tartu, Estonia.

PROBLEM: Autoimmune mechanisms are often involved in causing infertility. Among the possible targets of autoantibodies, the follicle-stimulating hormone (FSH) which regulates the follicular maturation in human ovary is a promising candidate. We aimed to study whether anti-FSH-antibodies might be involved in different clinical types of infertility. METHOD OF STUDY: The study group consisted of 178 patients (75 with polycystic ovary syndrome (PCOS), 103 with endometriosis) and 75 pregnant women. Female blood donors formed the control group (n = 85). Indirect enzyme-linked immunosorbent assay tests were performed using purified FSH as antigens and a synthetic peptide corresponding to the 78-93 region (V14D) of the human FSH beta-chain.

CONCLUSION: We showed that anti-FSH-antibodies were present in controls and their production decreased during pregnancy. Endometriosis and PCOS were associated with higher values of anti-FSH-immunoglobulin (Ig)A, anti-V14D-IgA, and endometriosis with anti-V14D-IgG. Our data suggest that anti-FSH-IgA could be a marker of ovarian disorders that cause infertility.

PMID: 16212648 [PubMed - indexed for MEDLINE]



1: Clin Exp Immunol. 2006 May;144(2):217-22.

The presence of antibodies to oxidative modified proteins in serum from polycystic ovary syndrome patients.
Palacio JR , Iborra A , Ulcova-Gallova Z , Badia R , Martínez P .
Unidad de Inmunología, Instituto de Biotecnología y Biomedicina, Universidad Autónoma de Barcelona, 08193 Barcelona, Spain. This email address is being protected from spambots. You need JavaScript enabled to view it.

Polycystic ovary syndrome (PCOS) affects 5-10% of women of reproductive age. Free radicals, as a product of oxidative stress, impair cells and tissue properties related to human fertility. These free radicals, together with the oxidized molecules, may have a cytotoxic or deleterious effects on sperm and oocytes, on early embryo development or on the endometrium. Aldehyde-modified proteins are highly immunogenic and circulating autoantibodies to new epitopes, such as malondialdehyde (MDA), may affect the reproductive system. Autoantibodies or elevated reactive oxygen species (ROS) in serum are often associated with inflammatory response. The purpose of this work is to investigate whether PCOS women show increased levels of oxidized proteins (protein-MDA) and anti-endometrial antibodies (AEA) in their sera, compared with control patients, and to determine whether AEA specificity is related to oxidized protein derivatives. Sera from 31 women [10 patients with PCOS (PCOS group) and 21 women with male factor of infertility (control group)] were chosen from patients attending for infertility. Anti-endometrial antibodies were determined by enzyme-linked immunosorbent assay (ELISA) with an endometrial cell line (RL-95). Antibodies against MDA modified human serum albumin (HSA-MDA) were also determined by ELISA. Oxidized proteins (protein-MDA) in serum were determined by a colorimetric assay. Patients with PCOS have significantly higher levels of AEA and anti-HSA-MDA, as well as oxidized proteins (protein-MDA) in serum than control patients. For the first time, we describe an autoimmune response in PCOS patients, in terms of AEA. The evidence of protein-MDA in the serum of these patients, together with the increased antibody reactivity to MDA-modified proteins (HSA-MDA) in vitro, supports the conclusion that oxidative stress may be one of the important causes for abnormal endometrial environment with poor embryo receptivity in PCOS patients.

J Reprod Immunol.[/b] 1999 Jan;42(1):79-84

Polycystic ovary syndrome and ovarian autoimmunity--assessment of ovarian antibodies by EIA .
Luborsky JL , Shatavi S , Adamczyk P , Chiong C , Llanes B , Lafniztzegger J , Soltes B , McGovern P , Santoro N .
Department of Obstetrics and Gynecology, Rush Medical College, Chicago, IL 60612, USA. This email address is being protected from spambots. You need JavaScript enabled to view it.

There are conflicting reports of an association of ovarian antibodies, detected by immunofluorescence, with polycystic ovary syndrome (PCOS). The objective of this study was to evaluate the association of ovarian autoimmunity with PCOS. A validated immunoassay for ovarian antibodies was used to assess serum from women with PCOS and with menopause and normal cycling women as controls. The frequency of ovarian antibodies was similar (25%) among the controls and PCOS. Thus, unlike the association of ovarian antibodies detected with this test in patients with unexplained infertility and premature menopause, the prevalence of ovarian antibody in patients with PCOS is not significantly different to controls.

Ovarian autoimmune disease and ovarian autoantibodies .
Luborsky J .
Reproductive Immunology, Department of Obstetrics and Gynecology, Rush Medical College, 1653 W. Congress Parkway, Chicago, IL 60612, USA.

Detection of specific autoantibodies remains the most practical clinical and research marker of autoimmune disease. The lack of consensus on ovary specific antibodies as a marker for ovarian autoimmunity has clinical and research consequences. The objective of this review is to summarize the evidence for ovarian autoimmunity and the detection of ovary specific autoantibodies in humans. Evidence favors the presence of an autoimmune disease of the ovary. Ovarian autoantibodies are associated primarily with premature ovarian failure (POF) and unexplained infertility. Variations in detection of ovarian autoantibodies are likely to be due to study design elements such as antibody test format, antigen preparation, and criteria for study and comparison groups. In addition, multiple targets appear to be involved in ovarian autoimmunity including ovarian cellular elements and oocyte related antigens. Many studies only assess one target antigen, leaving individuals with ovarian autoimmunity unidentified. The next most significant advance in characterizing ovarian autoimmunity will be definitive identification of the specific antigens and development of standardized tests based on use of specific antigens.

PMID: 12396892 [PubMed - indexed for MEDLINE]

Autoimmune Disease &amp; PCOS 17 Apr 2010 13:52 #790

  • Debra
  • Debra's Avatar Topic Author
  • Offline
  • Administrator
  • Administrator
  • CycleDiet Registered Dietitian
  • Posts: 2416
  • Karma: 3
  • Thank you received: 129
A new study related to autoimmune, PCOS and thyroiditis

Eur J Endocrinol. 2010 Mar 23. [Epub ahead of print]

High prevalence of polycystic ovary syndrome (PCOS) characteristics in girls with euthyroid chronic lymphocytic thyroiditis: A case-control study.
Ganie MA , Marwaha R , Aggarwal R , Singh S .

M Ganie, ENDOCRINOLOGY, SKIMS, SRINAGAR, 190014, India.

Abstract
Objective
: The aim was to find the prevalence of PCOS phenotype in adolescent euthyroid girls with chronic lymphocytic thyroiditis (CLT). Design: This was a prospective case-control study as part of an ongoing community-wide thyroid survey in Indian schools.

Methods: One hundred and seventy five girls with euthyroid CLT and 46 age-matched non-CLT girls underwent clinical, biochemical, hormonal and ultrasonographic evaluation for diagnosis of PCOS by Rotterdam 2003 criteria. All subjects underwent serum sampling for LH, FSH, Testosterone, DHEAS, FT4, TSH and anti-TPO antibodies. OGTT was undertaken for plasma glucose and insulin. Results: Significantly higher prevalence of PCOS was noted in girls with euthyroid CLT when compared to their control counterparts (46.8% vs. 4.3%, p=0.001). The CLT girls had higher BMI, waist circumference and systolic blood pressure (p=0.001). Mean number of menstrual cycles/ yr were 8.4 +/- 3.5 vs. 10.1 +/- 1.4 and mean Ferriman-Gallwey score was 11.9 +/- 3.5 vs. 3.0 +/-2.4 (p= 0.001) in cases vs. controls respectively. The fasting and post-prandial glucose and serum cholesterol were also higher in the cases (p=0.001). HOMA-IR was 4.4 +/- 4.2 vs. 2.3 +/- 2.7 in the cases vs. controls (p=0.001).

Conclusion: Higher prevalence of PCOS characteristics in euthyroid CLT girls when compared to controls, suggest possible role of autoimmune phenomenon in the etiopathogenesis of PCOS. Further studies are required to understand the pathogenic link between these two disorders.

PMID: 20332127 [PubMed - as supplied by publisher]

 

A study related to liver disease & PCOS (note: gluten sensitivity also associated with autoimmune liver disease)

J Hepatol. 2007 Sep;47(3):412-7. Epub 2007 May 24.

Nonalcoholic fatty liver disease in women with polycystic ovary syndrome.
Cerda C , Pérez-Ayuso RM , Riquelme A , Soza A , Villaseca P , Sir-Petermann T , Espinoza M , Pizarro M , Solis N , Miquel JF , Arrese M .

Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Comment in: J Hepatol. 2007 Sep;47(3):313-5.  

BACKGROUND/AIMS: Insulin resistance is a common feature of both nonalcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS), therefore, we hypothesize that PCOS and NAFLD may coexist. The aim of the present study was to determine the frequency and characteristics of NAFLD in women with PCOS.

 METHODS: A prospective study of patients with PCOS and no current pharmacological treatment was conducted. NAFLD was diagnosed by abdominal ultrasound following exclusion of alcohol consumption, viral, or autoimmune liver disease. Anthropometric variables, serum levels of glucose, insulin, lipids and aminotransferases, and HOMA index were determined.

RESULTS: Forty-one PCOS patients (mean age: 24.6+/-7.2yr, mean body mass index [BMI]: 30.3+/-7.0kg/m(2)) were included; 26 of 41 PCOS patients (63.4%) had insulin resistance and 17 (41.5%) had NAFLD. Nine of the NAFLD patients (64%) also had abnormal aminotransferases. Women with NAFLD and PCOS had a higher HOMA index and a higher waist-hip ratio than those with normal ultrasound. Patients with PCOS showed a higher frequency of NAFLD (41% vs. 19%) and insulin resistance (63% vs. 35.5%) than a control group.

CONCLUSIONS: NAFLD is frequent in patients with PCOS confirming a relevant clinical association between these two conditions. Women with PCOS should be screened for liver disease.

PMID: 17560682 [PubMed - indexed for MEDLINE]

Autoimmune Disease &amp; PCOS 19 Jun 2011 11:03 #791

  • Debra
  • Debra's Avatar Topic Author
  • Offline
  • Administrator
  • Administrator
  • CycleDiet Registered Dietitian
  • Posts: 2416
  • Karma: 3
  • Thank you received: 129


Fertil Steril. 2010 May 1;93(7):2291-4. Epub 2009 Mar 17
 

Serologic markers of autoimmunity in women with polycystic ovary syndrome.
Hefler-Frischmuth K , Walch K , Huebl W , Baumuehlner K , Tempfer C , Hefler L .

Source
Department of Laboratory Medicine, Wilhelminen Hospital Vienna, Vienna, Austria. This email address is being protected from spambots. You need JavaScript enabled to view it.


Abstract
OBJECTIVE:
To evaluate whether women with the polycystic ovary syndrome (PCOS) have an increased rate of elevated serum levels of common autoimmunologic parameters.

DESIGN:
Prospective case-control study.

SETTING:
Academic research institution.

PATIENT(S):
One hundred nine women with PCOS and 109 age-matched healthy controls.

INTERVENTION(S):
Peripheral venous puncture, ultrasonography, questionnaire.

MAIN OUTCOME MEASURE(S):
Serum levels of antinuclear antibodies (ANAs) were measured by immunometric enzyme immunoassay, serum levels of IgG class autoantibodies against histone, IgG class autoantibodies against nucleosomes, and IgG class autoantibodies against double-stranded (ds) DNA were measured by enzyme immunoassays.

RESULT(S):
Women with PCOS had significantly elevated serum levels of antihistone and anti-dsDNA antibodies, whereas serum levels of ANAs and antinucleosome antibodies were similar between the two groups. When serum levels of ANAs, antihistone, antinucleosomes, and anti-dsDNA antibodies were correlated with clinical and biochemical parameters, a significant correlation between serum levels of ANAs and serum TSH was established.

CONCLUSION(S):
Our study shows that serologic parameters of autoimmunity (i.e., antihistone and anti-dsDNA antibodies) are elevated in women with PCOS. A role of autoimmunologic processes in PCOS can be suspected.

Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

PMID:
19296936
[PubMed - indexed for MEDLINE]

Autoimmune Disease &amp; PCOS 21 Sep 2011 10:15 #792

  • Debra
  • Debra's Avatar Topic Author
  • Offline
  • Administrator
  • Administrator
  • CycleDiet Registered Dietitian
  • Posts: 2416
  • Karma: 3
  • Thank you received: 129
J Clin Endocrinol Metab. 2008 Apr;93(4):1310-6. Epub 2008 Jan 29.
A functional anti-Mullerian hormone gene polymorphism is associated with follicle number and androgen levels in polycystic ovary syndrome patients.
Kevenaar ME , Laven JS , Fong SL , Uitterlinden AG , de Jong FH , Themmen AP , Visser JA .

Source Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands.

Abstract CONTEXT:
The common characteristic of polycystic ovary syndrome (PCOS) is a disturbance in the selection of the dominant follicle, resulting in anovulation. In PCOS women, serum anti-Müllerian hormone (AMH) levels are elevated. Because AMH decreases FSH sensitivity in mice, the elevated AMH levels may contribute to the disturbed follicle selection in PCOS women.

OBJECTIVE: The objective of the study was to investigate the role of the AMH signaling pathway in the pathophysiology of PCOS using a genetic approach.

DESIGN: The association of the AMH Ile(49)Ser (rs10407022) and the AMH type II receptor -482 A>G (rs2002555) polymorphism with PCOS susceptibility and phenotype was studied in a large cohort of PCOS women.

SETTING/SUBJECTS: A total of 331 women with PCOS, 32 normoovulatory controls, and 3635 population-based controls were included.

MAIN OUTCOME MEASURES: Ovarian parameters, serum AMH, FSH, androgen, and estradiol levels were measured.

RESULTS: Genotype and allele frequencies for the AMH Ile(49)Ser and AMH type II receptor -482 A>G polymorphism were similar in PCOS women and controls. However, within the group of PCOS women, carriers of the AMH (49)Ser allele less often had polycystic ovaries (92.7 vs. 99.5%, P = 0.0004), lower follicle numbers (P = 0.03), and lower androgen levels, compared with noncarriers (P = 0.04). In addition, in vitro studies demonstrated that the bioactivity of the AMH (49)Ser protein is diminished, compared with the AMH (49)Ile protein (P < 0.0001).

CONCLUSIONS: Genetic variants in the AMH and AMH type II receptor gene do not influence PCOS susceptibility. However, our results suggest that the AMH Ile(49)Ser polymorphism contributes to the severity of the PCOS phenotype.


Ann Endocrinol (Paris). 2010 May;71(3):191-7. Epub 2010 Apr 2.
Anti-Müllerian hormone (AMH): regulator and marker of ovarian function.
van Houten EL , Themmen AP , Visser JA .

Source Department of Internal Medicine, Room Ee532, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

Abstract
In this review, the role of anti-Müllerian hormone (AMH) as a regulator and marker of ovarian function is described. Studies in mice showed that AMH is one of the intra-ovarian growth factors regulating primordial follicle recruitment and follicle-stimulating hormone (FSH) sensitivity of growing follicles in an inhibitory manner. Association studies of common variants of the AMH and AMHRII gene suggest that AMH may have a similar role in the human ovary. When it was discovered that serum levels AMH are correlated with the number of growing follicles, AMH gained further clinical interest as a marker for the quantitative aspect of ovarian reserve and as a diagnostic marker for polycystic ovary syndrome (PCOS).

Copyright 2010 Elsevier Masson SAS. All rights reserved.

Reproduction. 2006 Jan;131(1):1-9.
Anti-Müllerian hormone: a new marker for ovarian function .
Visser JA , de Jong FH , Laven JS , Themmen AP .

Source Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands. This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract
Anti-Müllerian hormone (AMH) is a member of the transforming growth factor beta family of growth and differentiation factors. In the ovary, AMH has an inhibitory effect on primordial follicle recruitment as well as on the responsiveness of growing follicles to follicle-stimulating hormone (FSH). The ovary-specific expression pattern in granulosa cells of growing nonselected follicles makes AMH an ideal marker for the size of the ovarian follicle pool. This review summarizes recent findings concerning AMH and its role as a marker for the quantitative aspect of ovarian reserve as well as ovarian dysfunction.
PMID:
16388003
[PubMed - indexed for MEDLINE]
Free full text http://www.ncbi.nlm.nih.gov/pubmed/16388003

Is PCOS an Autoimmune disease? 20 May 2013 11:30 #9295

  • Debra
  • Debra's Avatar Topic Author
  • Offline
  • Administrator
  • Administrator
  • CycleDiet Registered Dietitian
  • Posts: 2416
  • Karma: 3
  • Thank you received: 129
Eur J Obstet Gynecol Reprod Biol. 2013 Mar 30. pii: S0301-2115(13)00116-4. doi: 10.1016/j.ejogrb.2013.03.003. [Epub ahead of print]
High prevalence of chronic thyroiditis in patients with polycystic ovary syndrome.

Garelli S, Masiero S, Plebani M, Chen S, Furmaniak J, Armanini D, Betterle C.
Source

Endocrine Unit, Department of Medicine, Padova University, Padova, Italy.
Abstract
OBJECTIVE:

A higher prevalence (26.9% versus 8.3% of controls) of autoimmune thyroiditis (AIT) in polycystic ovary syndrome (PCOS) has been reported in one study to date. We aimed to evaluate the prevalence of clinical, subclinical, potential thyroid autoimmune diseases and other organ-specific autoimmunity in a group of Italian patients with PCOS.
STUDY DESIGN:

113 consecutive patients referred to our endocrinology unit as outpatients over 18 months, and diagnosed with PCOS according to the Rotterdam criteria, were included in the study, and 100 age-matched healthy women were enrolled as controls. Each patient was evaluated for family and personal history of autoimmune and non-autoimmune diseases and tested for autoantibodies against thyroperoxidase, thyroglobulin, parietal cells, intrinsic factor, adrenal-cortex, 21-hydroxylase, steroid-producing cells, 17-alpha-hydroxylase, side-chain cleavage enzyme, islet-cells, glutamic-acid decarboxylase, nuclei and mitochondria. All patients had serum TSH, FT4 and FT3 tested and patients with thyroid autoantibodies and/or abnormal TSH levels had an ultrasound thyroid scan. An oral glucose tolerance test and measurements of serum anti-Mullerian hormone (AMH) and inhibin B levels were carried out.
RESULTS:
AIT was present in 30/113 (27%) patients compared with 8% of controls (p<0.001). Subclinical hypothyroidism was detected in 13/30 (43%) patients with AIT; the remaining patients had normal thyroid function. The prevalence of non-thyroid autoantibodies in PCOS patients was not different from controls. AMH concentration was higher in PCOS patients compared to controls, but there was no difference between AIT and non-AIT groups.
CONCLUSIONS:

The prevalence of AIT in patients with PCOS was significantly higher than in controls. No other autoimmune diseases were associated with PCOS. This observation suggests that PCOS patients should be screened for AIT.
www.ncbi.nlm.nih.gov/pubmed/23548659

Is PCOS an Autoimmune disease? 22 May 2015 14:27 #10232

  • Debra
  • Debra's Avatar Topic Author
  • Offline
  • Administrator
  • Administrator
  • CycleDiet Registered Dietitian
  • Posts: 2416
  • Karma: 3
  • Thank you received: 129
bump
  • Page:
  • 1
Time to create page: 0.170 seconds