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What is Gluten and Dairy Intolerance? What is the difference between an allergy and intolerance/sensitivity. Latest medical research. Open to the public.
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TOPIC: Spectrum of gluten-related disorders (study)

Spectrum of gluten-related disorders (study) 22 May 2013 00:44 #9297

  • Debra
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Open Access
Spectrum of gluten-related disorders: consensus
on new nomenclature and classification

Anna Sapone1,2, Julio C Bai 3, Carolina Ciacci 4, Jernej Dolinsek 5, Peter HR Green 6, Marios Hadjivassiliou 7, Katri Kaukinen 8, Kamran Rostami 9, David S Sanders10, Michael Schumann 11, Reiner Ullrich 11, Danilo Villalta 12, Umberto Volta 13, Carlo Catassi 1,14 and Alessio Fasano 1*

A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely
ignored by health care professionals. In only 10 years, key milestones have moved celiac disease from obscurity
into the popular spotlight worldwide. Now we are observing another interesting phenomenon that is generating
great confusion among health care professionals. The number of individuals embracing a gluten-free diet (GFD)
appears much higher than the projected number of celiac disease patients, fueling a global market of gluten-free
products approaching $2.5 billion (US) in global sales in 2010. This trend is supported by the notion that, along
with celiac disease, other conditions related to the ingestion of gluten have emerged as health care concerns. This
review will summarize our current knowledge about the three main forms of gluten reactions: allergic (wheat
allergy), autoimmune (celiac disease, dermatitis herpetiformis and gluten ataxia) and possibly immune-mediated
(gluten sensitivity), and also outline pathogenic, clinical and epidemiological differences and propose new
nomenclature and classifications.
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