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What is Gluten and Dairy Intolerance? What is the difference between an allergy and intolerance/sensitivity. Latest medical research. Open to the public.
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TOPIC: Obstetric and Gyn Problems in Women with untreated CD/Gluten

Obstetric and Gyn Problems in Women with untreated CD/Gluten 20 Feb 2007 14:34 #508

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Several studies have noted women with gluten intolerance and Celiac have a delayed onset of menstruation and early onset of menopause. Here's one Italian study that might be interesting to you.

J Clin Gastroenterol.1990 Feb;12(1):37-9.

Obstetric and Gynecological Problems in Women with Untreated Celiac Sprue.
Cattedra di Patologia Medica III, University of Milan, Italy.

We investigated the obstetric and gynecological history of 54 consecutive women (aged 16-62 years, median of 35 years) with newly diagnosed celiac sprue and 54 healthy controls matched for age, origin, and sexual behavior. The mean age of menarche was significantly delayed in these untreated patients with respect to controls (13.5 vs. 12.1 years; p less than 0.0001). Of the patients, 38.8% complained of amenorrhea, compared with 9.2% of the controls (p less than 0.001).

Thirty-eight patients and 38 controls were in reproductive age; they had a normal sexual life and did not use contraceptive measures. Five celiacs, but no controls, had repeated abortions (p less than 0.03).

Eight celiacs and six controls were in menopause, the mean age at onset being 45.5 and 49.5 years respectively.


PMID: 2303686 [PubMed - indexed for MEDLINE]

Obstetric and Gyn Problems in Women with untreated CD/Gluten 20 Feb 2007 22:41 #509

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Another study relating to nutrition:

J Clin Gastroenterol.2004 Aug;38(7):567-74.  

Gynecologic and obstetric findings related to nutritional status and adherence to a gluten-free diet in Brazilian patients with celiac disease.
Gastroenterology Service, Cajuru Hospital, Pontifical Catholic University of Parana, Curitiba, Parana, Brazil. This email address is being protected from spambots. You need JavaScript enabled to view it.

This study shows a broad analysis of gynaecological and obstetrical disturbances in patients with celiac disease in relation to their nutritional status and adherence to a gluten-free diet.

Seventy-six adult celiac patients were analyzed according to nutritional status and 18 children/adolescents to gluten-free diet adherence. As controls, 84 adults and 22 adolescents with irritable bowel syndrome were used. The significant findings were observed as follow: adult celiac patients, irrespective of the nutritional status, were younger than controls, presented delayed menarche, secondary amenorrhea, a higher percentage of spontaneous abortions, anemia and hypoalbuminemia.

No differences were observed regarding the number of pregnancies, age at menopause and duration of the reproductive period. After treatment, patients presented with normal pregnancies and one patient presented spontaneous abortion.

The adolescents who were not adherent to gluten-free diet presented delayed menarche and secondary amenorrhea. In conclusion, gluten per se could explain the disturbances and malnutrition would worsen the disease in a consequent vicious cycle. Therefore, celiac disease should be included in the screening of reproductive disorders.

PMID: 15232359 [PubMed - indexed for MEDLINE]

Obstetric and Gyn Problems in Women with untreated CD/Gluten 20 Feb 2007 22:46 #510

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Digestion. 1994;55(4):243-6.
Female fertility, obstetric and gynaecological history in coeliac disease.
 A case control study.


Sher KS , Mayberry JF .
Gastroenterology Research Unit, Leicester General Hospital, UK.

The purpose of this study was to investigate the incidence of infertility, abortions and perinatal mortality, age at menarche and menopause in coeliac disease (CD). It was a case control study in which patients and controls matched for age and sex were sent questionnaires about their fertility profile and other obstetric and gynaecological problems. All 80 patients and 70 controls replied but only 68 groups could be matched for this study. The mean age of menarche in patients was significantly older at 13.6 years than in controls at 12.7 years.

The mean age at menopause in patients and controls were 47.6 and 50.1 years respectively. The study showed the mean number of children born to patients with CD was significantly less at 1.9 (SD +/- 0.9) compared to 2.5 (SD +/- 1.2) in controls. Before diagnosis the mean number of children born to patients was 1.4 and 1.8 in controls. After diagnosis and treatment, patients had 0.5 children (SD +/- 0.9) compared to 0.7 in controls (SD +/- 1.2).

It seems likely that the overall difference in fertility is due to relative infertility prior to diagnosis and its correction by a gluten-free diet. Significantly more conceptions amongst women with CD (15%) ended in miscarriage prior to diagnosis than amongst controls (6%). After diagnosis and treatment the rate of miscarriage was similar at 7 and 12% respectively. There were 120 live babies and 7 stillbirths to patients compared with 161 live babies and 1 stillbirth to controls. In conclusion, this study shows that patients with CD are subfertile and have an increased incidence of stillbirths and perinatal deaths.

PMID: 8063029 [PubMed - indexed for MEDLINE]

Obstetric and Gyn Problems in Women with untreated CD/Gluten 01 Nov 2009 20:42 #511

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