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What is Gluten and Dairy Intolerance? What is the difference between an allergy and intolerance/sensitivity. Latest medical research. Open to the public.
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TOPIC: Spectrum of Gluten-related Disorders:

Spectrum of Gluten-related Disorders: 12 Jun 2012 19:55 #541

  • Debra
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Long time in coming: (free full access)

Spectrum of gluten-related disorders: consensus on new nomenclature and classification

Anna Sapone 1 , 2 , Julio C Bai 3 , Carolina Ciacci 4 , Jernej Dolinsek 5 , Peter HR Green 6 , Marios Hadjivassiliou 7 , Katri Kaukinen 8 , Kamran Rostami 9 , David S Sanders 10 , Michael Schumann 11 , Reiner Ullrich 11 , Danilo Villalta 12 , Umberto Volta 13 , Carlo Catassi 1 , 14 and Alessio Fasano 1 *

A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10 years, key milestones have moved celiac disease from obscurity into the popular spotlight worldwide. Now we are observing another interesting phenomenon that is generating great confusion among health care professionals. The number of individuals embracing a gluten-free diet (GFD) appears much higher than the projected number of celiac disease patients, fueling a global market of gluten-free products approaching $2.5 billion (US) in global sales in 2010. This trend is supported by the notion that, along with celiac disease, other conditions related to the ingestion of gluten have emerged as health care concerns. This review will summarize our current knowledge about the three main forms of gluten reactions: allergic (wheat allergy), autoimmune (celiac disease, dermatitis herpetiformis and gluten ataxia) and possibly immune-mediated (gluten sensitivity), and also outline pathogenic, clinical and epidemiological differences and propose new nomenclature and classifications.
BMC Medicine 2012, 10:13 doi:10.1186/1741-7015-10-13

The electronic version of this article is the complete one and can be found online at:

Received:9 October 2011 Accepted:7 February 2012 Published:7 February 2012
© 2012 Sapone et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Spectrum of Gluten-related Disorders: 12 Jun 2012 20:08 #542

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