Forgot Password       


The forum is in read only mode.
Welcome, Guest
Username: Password: Remember me
What is Gluten and Dairy Intolerance? What is the difference between an allergy and intolerance/sensitivity. Latest medical research. Open to the public.
  • Page:
  • 1

TOPIC: Wheat, Dairy Antibodies Found in Some with Bipolar

Wheat, Dairy Antibodies Found in Some with Bipolar 23 Jan 2017 11:23 #10869

  • Debra
  • Debra's Avatar Topic Author
  • Offline
  • Administrator
  • Administrator
  • CycleDiet Registered Dietitian
  • Posts: 2416
  • Karma: 3
  • Thank you received: 129
I've had several clients over the years who have been diagnosed with Bipolar disorder, they've benefited from a dairy-free and gluten-free diet. This research looks at antibodies from wheat, casein (from cow's milk) and yeast. More evidence of the gut-brain connection.

Bipolar Disord. 2014 May;16(3):230-40. doi: 10.1111/bdi.12159. Epub 2013 Dec 6.

Seroreactive marker for inflammatory bowel disease and associations with antibodies to dietary proteins in bipolar disorder.

Severance EG1, Gressitt KL, Yang S, Stallings CR, Origoni AE, Vaughan C, Khushalani S, Alaedini A, Dickerson FB, Yolken RH.
Author information
Immune sensitivity to wheat glutens and bovine milk caseins may affect a subset of individuals with bipolar disorder. Digested byproducts of these foods are exorphins that have the potential to impact brain physiology through action at opioid receptors. Inflammation in the gastrointestinal (GI) tract might accelerate exposure of food antigens to systemic circulation and help explain elevated gluten and casein antibody levels in individuals with bipolar disorder.

We measured a marker of GI inflammation, anti-Saccharomyces cerevisiae antibodies (ASCA), in non-psychiatric controls (n = 207), in patients with bipolar disorder without a recent onset of psychosis (n = 226), and in patients with bipolar disorder with a recent onset of psychosis (n = 38). We compared ASCA levels to antibodies against gluten, casein, Epstein-Barr virus (EBV), herpes simplex virus 1 (HSV-1), influenza A, influenza B, measles, and Toxoplasma gondii.

Elevated ASCA conferred a 3.5-4.4-fold increased odds ratio of disease association (age-, race-, and gender-corrected multinomial logistic regressions, p ? 0.00001) that was independent of type of medication received. ASCA correlated with food antibodies in both bipolar disorder groups (R(2) = 0.29-0.59, p ? 0.0005), and with measles and T. gondii immunoglobulin G (IgG) in the recent onset psychosis bipolar disorder group (R(2) = 0.31-0.36, p ? 0.004-0.01).

Elevated seropositivity of a GI-related marker and its association with antibodies to food-derived proteins and self-reported GI symptoms suggest a GI comorbidity in at least a subgroup of individuals with bipolar disorder. Marker seroreactivity may also represent part of an overall heightened activated immune state inherent to this mood disorder.

? 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

autoimmunity; environment; gastrointestinal; immunology; infection; mood disorder

Wheat, Dairy Antibodies Found in Some with Bipolar 11 Jan 2018 07:35 #11000

  • louisvuitton
  • louisvuitton's Avatar
  • Offline
  • Fresh Boarder
  • Fresh Boarder
  • Posts: 7
  • Thank you received: 1
Hi Debra,
Good informative post.
Nice to see you post such informative posts in this.
I am new to this forum.
I am interested in weight loss topics.
Please post nice piece of information on weight loss diets. This is my request.
  • Page:
  • 1
Time to create page: 0.145 seconds