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What is Gluten and Dairy Intolerance? What is the difference between an allergy and intolerance/sensitivity. Latest medical research. Open to the public.
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TOPIC: Gluten Intolerance cause for nonresponsive to levothyroxine

Gluten Intolerance cause for nonresponsive to levothyroxine 05 Mar 2009 13:04 #594

  • Debra
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: Arq Bras Endocrinol Metabol 2005 Aug;49(4):599-603. Epub 2005 Oct 19.Links


[Autoimmune hypothyroidism nonresponsive to high doses of levothyroxine and severe hypocalcemia]

Silva CM , Souza MV .
Serviço de Endocrinologia, Instituto Estadual de Diabetes e Endocrinologia Luis Capriglione, Rio de Janeiro, RJ.

The factors that make difficult the normalization of TSH in hypothyroidism need special attention because some patients on thyroxine replacement do not maintain a normal TSH. We report a 50 year-old woman with autoimmune hypothyroidism of difficult compensation, associated with anemia, hypocalcemia with a previous episode of tetany, hypomagnesemia, psychologic alterations and important weight loss. After compensation of the hypothyroidism with doses of L-thyroxine as high as 325 microg/day, the hypothesis of a malabsorptive syndrome was raised.

 Celiac disease was confirmed by elevated serum antigliadin antibody. A gluten-free diet was instituted which improved the symptoms associated with malabsorption and reduced the L-thyroxine requirement to 125 microg/day. Because several studies have shown an association of both diseases, a routine screening for celiac disease has been widely proposed in patients with autoimmune thyroid disease.

PMID: 16358091 [PubMed - indexed for MEDLINE]

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