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What is Gluten and Dairy Intolerance? What is the difference between an allergy and intolerance/sensitivity. Latest medical research. Open to the public.
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TOPIC: Celiac Disease and Associated Autoimmune conditions

Celiac Disease and Associated Autoimmune conditions 05 Mar 2009 13:25 #596

  • Debra
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1: Clin Diagn Lab Immunol 2001 Jul;8(4):678-85.

Celiac disease-associated autoimmune endocrinopathies.

Kumar V , Rajadhyaksha M , Wortsman J .
IMMCO Diagnostics, Inc., Buffalo, New York 14228, USA. This email address is being protected from spambots. You need JavaScript enabled to view it.

Celiac disease (CD) is an autoimmune disorder induced by gluten intake in genetically susceptible individuals. It is characterized by the presence of serum antibodies to endomysium, reticulin, gliadin, and tissue transglutaminase. The incidence of CD in various autoimmune disorders is increased 10- to 30-fold in comparison to the general population, although in many cases CD is clinically asymptomatic or silent. The identification of such cases with CD is important since it may help in the control of type I diabetes or endocrine functions in general, as well as in the prevention of long-term complications of CD, such as lymphoma.

It is believed that CD may predispose an individual to other autoimmune disorders such as type I diabetes, autoimmune thyroid, and other endocrine diseases and that gluten may be a possible trigger. The onset of type I diabetes at an early age in patients with CD, compared to non-CD, and the prevention or delay in onset of diabetes by gluten-free diet in genetically predisposed individuals substantiates this antigen trigger hypothesis. Early identification of CD patients in highly susceptible population may result in the treatment of subclinical CD and improved control of associated disorders.

PMID: 11427410 [PubMed - indexed for MEDLINE]

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