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What is Gluten and Dairy Intolerance? What is the difference between an allergy and intolerance/sensitivity. Latest medical research. Open to the public.
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TOPIC: Divergence of Gut permeability, Two gluten-associated cond

Divergence of Gut permeability, Two gluten-associated cond 12 Jun 2012 13:20 #635

  • Debra
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This is FINALLY proof of non-celiac gluten sensitivity or GS. We've known for a very long time that it was different from celiac but doctors were afraid to make a diagnosis because they didn't know what it was. The diagnosis is still illusive because the only lab tests available are non-traditional or non-mainstream. We still have a long way to go in order to get a viable lab test. But, as I have always said over the years of recommending the GF diet (after ruling out celiac)...The Proof is in the Diet! (full access to article)

Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity

 Anna Sapone 1 , 2 , Karen M Lammers 2 , Vincenzo Casolaro 2 , 3 , Marcella Cammarota 4 , Maria T Giuliano 4 , Mario De Rosa 4 , Rosita Stefanile 5 , Giuseppe Mazzarella 5 , Carlo Tolone 6 , Maria I Russo 7 , Pasquale Esposito 7 , Franca Ferraraccio 8 , Maria Cartenì 4 , Gabriele Riegler 1 , Laura de Magistris 1 and Alessio Fasano 2 *


Background Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten. Gluten-sensitive individuals (GS) cannot tolerate gluten and may develop gastrointestinal symptoms similar to those in CD, but the overall clinical picture is generally less severe and is not accompanied by the concurrence of tissue transglutaminase autoantibodies or autoimmune comorbidities. By studying and comparing mucosal expression of genes associated with intestinal barrier function, as well as innate and adaptive immunity in CD compared with GS, we sought to better understand the similarities and differences between these two gluten-associated disorders.

BMC Medicine 2011, 9:23 doi:10.1186/1741-7015-9-23

The electronic version of this article is the complete one and can be found online at:

Received:21 January 2011 Accepted:9 March 2011 Published:9 March 2011
© 2011 Sapone et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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